Antimicrobials
Eravacycline

Eravacycline

Restricted

Low
N/A
$$$ ($101-$200/day)

Spectrum of Activity

General Information

  • Infusion site reactions

  • N/V/D

  • CYP3A4 Inducers (Strong): May decrease the serum concentration of Eravacycline.
    • Management: Increase the eravacycline dose to 1.5 mg/kg every 12 hours when combined with strong CYP3A4 inducers
  • Distribution: Vdss: ~321 L (~4 L/kg)

  • Protein binding: 79% to 90% (increases with increasing plasma concentrations)

  • Metabolism: Primarily by CYP3A4- and FMO-mediated oxidation

  • Half-life elimination: 20 hours

  • Excretion: Urine: ~34% (20% as unchanged drug); Feces: 47% (17% as unchanged drug)