Tier 1
Allergic reactions
Diarrhea, nausea, vomiting
Absorption: Oral: 50%
Distribution: Into bile; penetration into CSF occurs with inflamed meninges only
Protein binding: 15% to 18%
Half-life elimination: 1 to 1.8 hours; Anuric patients: 8 to 20 hours
Time to peak serum concentration: Oral: Within 1 to 2 hours
Excretion: Urine (∼90%, unchanged within 24 hours); feces
For oral therapy, including oral step-down therapy after IV ampicillin, oral amoxicillin is preferred over oral ampicillin due to improved bioavailability and absorption