Diagnose infection based on:
Typically polymicrobial with aerobic gram-positive cocci, aerobic gram-negative rods, and anaerobes
No concern for anaerobes; anaerobic coverage is not necessary
Hold antibiotics prior to cultures
Obtain post-debridement cultures and de-escalate based upon susceptibilities
Lipsky BA, Berendt AR, Cornia PB et al. 2012 Infectious Diseases Society of America Clinical Practice Guidelines for the Diagnosis and Treatment of Diabetic Foot Infections. Clin Infect Dis 2012;54(12):132-173.
Guidelines