Clostridium difficile Infection (CDI)
Severe

Severe

Clinical Manifestation

CDI with:

  • WBC ≥ 15,000 cells/mm³ OR
  • SCr ≥ 1.5 mg/dL

Empiric Treatment

OR

ID restricted with following criteria restriction:

  • Age ≥ 65 years, and/or
  • Immunocompromised, defined as:
    • Malignancy
    • HIV/AIDS with CD4 count ≤ 200 cells/mm³ (or ≤ 14%)
    • Receiving immunosuppressive therapy or steroids ≥ prednisone 20 mg/day (or equivalent)
    • Solid organ/stem cell transplant recipient