Guidelines
Acyclovir Renal Dosing

Acyclovir Renal Dosing

Not On Dialysis: IV Therapy

  • CrCl >50 mL/min: 5mg/kg IV q8hr
  • CrCl 30-50 mL/min: 5mg/kg IV q12hr
  • CrCl 10-29 mL/min: 5mg/kg IV q24hr
  • CrCl <10 mL/min: 2.5mg/kg IV q24hr
  • CrCl >50 mL/min: 10mg/kg IV q8hr
  • CrCl 30-50 mL/min: 10mg/kg IV q12hr
  • CrCl 10-29 mL/min: 10mg/kg IV q24hr
  • CrCl <10 mL/min: 5mg/kg IV q24hr
  • CrCl ≥30 mL/min: 250mg/m² IV q12hr
  • CrCl 10-29 mL/min: 250mg/m² IV q24hr
  • CrCl <10 mL/min: 125mg/m² IV q24hr
  • CrCl ≥30 mL/min: 200mg IV q12hr
  • CrCl 10-29 mL/min: 200mg IV q24hr
  • CrCl <10 mL/min: 100mg IV q24hr

Not On Dialysis: PO Therapy

  • CrCl ≥10 mL/min: 400mg PO TID
  • CrCl <10 mL/min: 400mg PO BID
  • CrCl ≥30 mL/min: 800mg PO 5x/day
  • CrCl 10-29 mL/min: 800mg PO TID
  • CrCl <10 mL/min: 800mg PO BID
  • CrCl ≥10 mL/min: 400mg PO BID
  • CrCl <10 mL/min: 200mg PO BID
  • CrCl ≥10 mL/min: 800mg PO BID
  • CrCl <10 mL/min: 400mg PO BID

Continuous Ambulatory Peritoneal Dialysis (CAPD)

Continuous Renal Replacement Dosing

5mg/kg IV q24hr

7.5mg/kg IV q24hr