Antimicrobials
Polymyxin B

Polymyxin B

Restricted

Low
N/A
$$/day (70kg patient)

Spectrum of Activity

General Information

Multi-Drug Resistant (MDR) Pseudomonas, Acinetobacter, and Enterobacterales infections. 

Colistin is preferred for urinary tract infections.

Laboratory:

  • BMP
  • Urine output

Clinical:

  • Mental status changes/seizures or peripheral neuropathy
  • Nephrotoxicity
  • Neurotoxicity

Antimicrobial class: Polymyxin

Pregnancy category: C

Average serum half life: 6 hours

Lung penetration: Poor

Urine penetration: Therapeutic

CSF penetration: Poor