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Antimicrobials
Nafcillin

Nafcillin

Restricted

Low
N/A
$$$/day

Spectrum of Activity

General Spectrum of Activity
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General Information

Mostly used for MSSA infections.

Periodic CBC and renal and hepatic function tests.

  • Allergy (immediate or delayed)
  • Seizures
  • Cytopenias
  • Eosinophilia
  • Interstitial nephritis
  • Abnormal liver enzymes
  • GI effects
  • May increase serum methotrexate levels
  • May DECREASE INR in patients receiving warfarin
  • Can cause phlebitis if given peripherally
  • Central line preferred for tolerance

Antimicrobial class: Antistaphylococcal Penicillin

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic