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Antimicrobials
Rifabutin

Rifabutin

N/A
Moderate (40 to 70%)

Spectrum of Activity

General Spectrum of Activity
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Dosing

General Information

Use in Mycobacterium tuberculosis when rifampin cannot be used due to drug-drug interactions.

Lab

  • Periodic CBC to monitor for neutropenia, thrombocytopenia

Clinical

  • Multiple drug interactions
  • Polymyalgia
  • Uveitis

Rifabutin is a less potent CYP3A inducer than rifampin. Review medications carefully.

  • Should never be used as monotherapy
  • May discolor bodily secretions (yellow-reddish); caution in contact lens wearers

Antimicrobial class: Antimicobacterial

Average serum half life: 35 hrs

Route of Elimination: Renal, feces