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Antimicrobials
Minocycline

Minocycline

Restricted

Low
Excellent
$(PO)/$$$$(IV)/day

Spectrum of Activity

General Spectrum of Activity
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General Information

Typically reserved for drug-resistant organisms.

Non-infectious indications: Acne (PO only).

Liver and renal function.

  • Photosensitivity
  • Skin rash
  • Esophagitis
  • Tooth and body secretion discoloration
  • Light-headedness, dizziness, vertigo
  • Di-valent cations: decrease absorption of minocycline
  • Increased serum concentration of Lithium
  • Increased INR with warfarin

Antimicrobial class: Tetracycline

Pregnancy category: D

Average serum half life: 15-23 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Moderate