General Spectrum of Activity
Treatment and prophylaxis of CMV disease in immunocompromised hosts.
Imipenem/cilastatin: increase risk of seizure when given with ganciclovir/valganciclovir.
Cyclosporine and Amphotericin B: enhanced nephrotoxic effects of cyclosporine and amphotericin B when co-administered with ganciclovir/valganciclovir.
Mycophenolate: increased serum concentration of ganciclovir/valganciclovir when co-administered.
Teratogenic/carcinogenic - do not crush the valganciclovir tablets and avoid direct skin and/or mucous membrane contact with broken or crushed tablets.
Valganciclovir should be taken with food to optimize absorption.
Antimicrobial class: Antiviral - synthetic guanine analog
Pregnancy category: C
Average serum half life: 4 hours
Urine penetration: High
CSF penetration: Moderate/high
Lung penetration: Moderate
Biliary penetration: Moderate