Antimicrobials
Valacyclovir

Valacyclovir

None
Moderate (40 to 70%)

Spectrum of Activity

Dosing

General Information

Treatment and prophylaxis of HSV-1 and HSV-2, VZV

Laboratory

  • BMP and CBC periodically

Generally very well tolerated.

Rare

  • Nausea/vomiting, rash
  • CNS (agitation, dizziness, confusion, seizures)
  • Transaminase elevation
  • Anemia
  • Neutropenia
  • Hypotension

Pro-drug of acyclovir with improved absorption and more convenient dosing compared to oral acyclovir.

Antimicrobial class: Antiviral - synthetic guanine analog

Pregnancy category: B

Average serum half life: 3 hours

Urine penetration: High

CSF penetration: High