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Pyrazinamide
Renal

Renal

Not On Dialysis

CrCl >50 mL/min

25mg/kg daily

CrCl 30-50 mL/min

25mg/kg daily

CrCl 10-29 mL/min

25mg/kg 3x per week (round up)(MWF preferred)

CrCl <10 mL/min

25mg/kg 3x per week (round up)(MWF preferred)

Intermittent Hemodialysis (IHD)

25mg/kg 3x per week post HD

Continuous Ambulatory Peritoneal Dialysis (CAPD)

25mg/kg 3x per week

Note

Use Total BW up to BMI 30, then Adjusted BW for BMI >30 per Public Health guidance.