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Antimicrobials
Ceftolozane-Tazobactam (Zerbaxa)

Ceftolozane-Tazobactam (Zerbaxa)

Restricted

High
N/A
$$$$/day

Spectrum of Activity

General Spectrum of Activity
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General Information

  • Reserved for patients with little or no alternative treatment options
  • Management of documented CRE infection
  • Positive direct coombs test
  • Diarrhea
  • N/V
  • Pruritis
  • Hypersensitivity reactions

Medication cost calculated per day (24 hours) of therapy for the average adult dose (70kg) of 1.5h IV q8h.

Antimicrobial class: Cephalosporin combination

Pregnancy category: B

Average serum half life:

  • Ceftolozane: ~3 to 4 hours
  • Tazobactam: ~2 to 3 hours

Urine penetration: Therapeutic