Trimethoprim-Sulfamethoxazole (Bactrim, Septra)
Adult

Adult

Urinary Tract Infection

1 DS tab PO BID

Skin/Soft Tissue Infection

1 DS tab PO BID (2 DS tabs if BMI > 40)

Stenotrophomonas Infections

15-20 mg/kg/day (TMP component) IV/PO in 2-3 divided doses

Pneumocystis Pneumonia

Treatment

15 mg/kg/day (TMP component) IV/PO in 2-3 divided doses

Prophylaxis

 1 DS tab PO daily

Notes

  • Each DS tab = TMP 160mg-SMX 800mg
  • Each SS tab = TMP 80mg-SMX 400mg

If actual body weight > 120% ideal body weight, use AdjBW for weight-based doses

Highly bioavailable, switch IV to PO when stable or taking orals