General Spectrum of Activity
Broad spectrum agent with anti-pseudomonal activity. Covers Gram-negative anaerobes and does not need to be used in combination with metronidazole.
Used for severe infections including:
Allergy/rash (immediate or delayed)
Cytopenias- esp. thrombocytopenia
Abnormal liver enzymes
Incr. levels of methotrexate.
Medication cost calculated per day (24 hours) of therapy for the average adult dose (70kg) of 3.375g q8h.
Antimicrobial class: Ureidopenicillin with a beta-lactamase inhibitor
Pregnancy category: B
Average serum half life: 1 hour
Biliary penetration: Therapeutic
CSF penetration: Poor
Lung penetration: Therapeutic
Urine penetration: Therapeutic