Piperacillin-Tazobactam (Zosyn)

Piperacillin-Tazobactam (Zosyn)



General Information

Broad spectrum agent with anti-pseudomonal activity. Covers Gram-negative anaerobes and does not need to be used in combination with metronidazole.  

Used for severe infections including:

  • Pneumonia
  • Intra-abdominal
  • UTI
  • Polymicrobial skin and soft tissue infection
  • Febrile neutropenia
  • Allergy/rash (immediate or delayed)

  • Cytopenias- esp. thrombocytopenia

  • Eosinophilia

  • Interstitial nephritis

  • Abnormal liver enzymes

Incr. levels of methotrexate.

Medication cost calculated per day (24 hours) of therapy for the average adult dose (70kg) of 3.375g q8h.

Antimicrobial class: Ureidopenicillin with a beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic