General Spectrum of Activity
Assess for peripheral/optic neuropathy with prolonged therapy (>6wks) or if symptoms develop.
GI symptoms common - Especially nausea/vomiting and metallic taste.
Peripheral/optic neuropathy with extended therapy.
Disulfiram-like reaction (severe vomiting).
Rare neurotoxicity including aseptic meningitis and encephalopathy.
Ethanol - Disulfiram-like reaction.
Major substrate CYP2A6 and weak CYP2C9 inhibitor increases levels of:
Antimicrobial class: Nitroimidazole
Pregnancy category: B
Average serum half life: 8 hours
Urine penetration: Poor
Lung penetration: Therapeutic
CSF penetration: Therapeutic
Biliary penetration: Therapeutic