Antimicrobials
Linezolid

Linezolid

Restricted

Low
Excellent
$(PO)/$$$(IV)/day

Spectrum of Activity

General Information

Targeted or empiric therapy for gram positive infections including skin and soft tissue and pneumonia.

Covers MRSA and VRE.

CBC at least once/week for treatment.

Peripheral sensory and visual function for therapy >3 months or if symptoms develop on therapy.

Signs and symptoms of serotonin syndrome, especially if on concomitant serotonergic agents.

SSRI and other serotonergics/MAOIs - Increased risk of serotonin syndrome.

Rifampin decreases linezolid levels.

Antimicrobial class: Oxazolidinone

Pregnancy category: C

Average serum half life: 5 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic