Antimicrobials
Imipenem-Cilastatin (Primaxin)

Imipenem-Cilastatin (Primaxin)

Restricted

Medium
N/A
$$$/day

Spectrum of Activity

General Information

ESBL Enterobacterales infections.

Laboratory:

  • BMP and CBC

Clinical

  • Mental status changes/seizures
  • Immediate and delayed-type allergy

  • GI disturbance

  • Cytopenias, positive Coombs

  • Liver enzyme abnormalities

  • CNS effects including confusional states and seizures

  • Valproic acid: May decrease serum concentrations of valproic acid
  • Ganciclovir/Valganciclovir - May increase risk of seizures
  • Cyclosporine - May enhance neurotoxic effects of imipenem

Medication cost calculated per day (24 hours) of imipenem therapy for the average adult dose (70kg) of 500mg IV q6h.

Antimicrobial class: Carbapenem

Pregnancy category: C

Average serum half life: 1 hour

Urine penetration: Therapeutic

CSF penetration: Moderate