General Spectrum of Activity
Targeted therapy of ESBL infections and other resistant gram-negative infections.
Empiric therapy when broad spectrum of carbapenems is desired without the need for anti-pseudomonal activity.
Immediate and delayed-type allergy
Cytopenias, eosinophilia, positive Coombs
Liver enzyme abnormalities
Seizure risk lower than other carbapenems
Valproic acid - Carbapenems decrease valproate levels and may decrease seizure threshold.
Medication cost calculated per day (24 hours) of therapy for the average adult dose (70kg) of 1g IV q24h.
Antimicrobial class: Carbapenem
Pregnancy category: B
Average serum half life: 4 hours
Urine penetration: Therapeutic
Lung penetration: Therapeutic
Biliary penetration: Moderate