GI upset and erosive esophagitis
Photosensitivity rash
Teeth staining
Divalent cations - decreased absorption
Increased digoxin levels
Increased INR with warfarin
Some anticonvulsants can decrease doxycycline levels
Almost completely absorbed from GI tract → utilize PO when enteral access available
Antimicrobial class: Tetracycline
Pregnancy category: D
Average serum half life: 18 hours
Biliary penetration: Therapeutic
CSF penetration: Poor
Lung penetration: Therapeutic
Urine penetration: Low