Antimicrobials
Doxycycline

Doxycycline

Low
Excellent
$(PO)/$$$(IV)/day

Dosing

General Information

  • Purulent Skin and soft tissue infection
  • Community acquired pneumonia
  • Malaria prophylaxis
  • Zoonoses
  • Methicillin-resistant Staphylococcus aureus infections
  • GI upset and erosive esophagitis

  • Photosensitivity rash

  • Teeth staining

  • Divalent cations - decreased absorption

  • Increased digoxin levels

  • Increased INR with warfarin

  • Some anticonvulsants can decrease doxycycline levels

Almost completely absorbed from GI tract → utilize PO when enteral access available

Antimicrobial class: Tetracycline

Pregnancy category: D

Average serum half life: 18 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Low