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Antimicrobials
Daptomycin

Daptomycin

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Low
N/A
$$$/day

Spectrum of Activity

General Spectrum of Activity
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General Information

Targeted therapy of resistant gram-positive infections with MRSA (particularly when vancomycin MIC≥2) and VRE including endovascular infection.

Creatine kinase weekly.

  • Myopathy including rhabdomyolysis
  • Rash
  • Phlebitis

Statins and fibrates - Increased myopathy.

Monitor creatine kinase while on daptomycin therapy.

  • Inactivated by pulmonary surfactant → insufficient for pulmonary infection
  • Medication cost calculated per day (24 hours) of therapy for the average adult dose (70kg) of 500mg IV q24h

Antimicrobial class: Cyclic Lipopeptide

Pregnancy category: B

Average serum half life: 9 hours

Urine penetration: Therapeutic

Lung penetration: Inactivated by surfactant

CSF penetration: Poor