General Information

Pseudomonal and other gram negative infections of urinary tract, bone/joint, abdomen, ventilator-associated pneumonia and other sites.

For uncomplicated infections consider alternative agents.

Monitor QTc in patients with increased risk.

  • QTc prolongation
  • Dysglycemia
  • Tendinopathy and rupture
  • GI upset
  • Rash
  • Retinal detachment
  • CNS toxicity including confusion, psychosis
  • Peripheral neuropathy
  • Weakness exacerbation in myasthenia gravis
  • Association with aortic rupture
  • Photosensitivity

CYP inhibitor - Multiple interactions possible.

QTc prolongation - Increased risk with other agents that prolong QTc.

Divalent & trivalent cations including Al, Ca, Fe, Mg (antacids, dairy products, iron supplements, some enteral feeds) - Decreased absorption.

Cyclosporine - Increased levels of cyclosporine.

Warfarin - Increased INR.

Methadone - Lowered seizure threshold.

Medication cost calculated per day (24 hours) of therapy for the average adult dose (70kg) of 500mg PO q12h or 400mg IV q12h.

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 4 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Moderate

Biliary penetration: Therapeutic