Pseudomonal and other gram negative infections of urinary tract, bone/joint, abdomen, ventilator-associated pneumonia and other sites.
For uncomplicated infections consider alternative agents.
Monitor QTc in patients with increased risk.
CYP inhibitor - Multiple interactions possible.
QTc prolongation - Increased risk with other agents that prolong QTc.
Divalent & trivalent cations including Al, Ca, Fe, Mg (antacids, dairy products, iron supplements, some enteral feeds) - Decreased absorption.
Cyclosporine - Increased levels of cyclosporine.
Warfarin - Increased INR.
Methadone - Lowered seizure threshold.
Medication cost calculated per day (24 hours) of therapy for the average adult dose (70kg) of 500mg PO q12h or 400mg IV q12h.
Antimicrobial class: Fluoroquinolone
Pregnancy category: C
Average serum half life: 4 hours
Urine penetration: Therapeutic
Lung penetration: Therapeutic
CSF penetration: Moderate
Biliary penetration: Therapeutic
Antimicrobials
