Cephalexin
Renal

Renal

Not On Dialysis

Uncomplicated Cystitis, Streptococcal Pharyngitis
  • CrCl >50 mL/min: 500mg BID

  • CrCl 30-50 mL/min: 250mg BID

  • CrCl 10-29 mL/min: 250mg BID

  • CrCl <10 mL/min: 250mg daily

Skin/Soft Tissue, Pyelonephritis
  • CrCl >50 mL/min: 500mg QID

  • CrCl 30-50 mL/min: 500mg BID

  • CrCl 10-29 mL/min: 500mg BID

  • CrCl <10 mL/min: 500mg daily

Intermittent Hemodialysis (IHD)

Uncomplicated Cystitis, Streptococcal Pharyngitis

250mg qPM

Skin/Soft Tissue, Pyelonephritis

500mg qPM

Continuous Ambulatory Peritoneal Dialysis (CAPD)

Uncomplicated Cystitis, Streptococcal Pharyngitis

250mg daily

Skin/Soft Tissue, Pyelonephritis

500mg daily

Note

For all beta-lactams, if patient weighs >30% IBW, consider using upper end of dosing recommendations