Low (20 to 40%)


General Information

  • Community-acquired pneumonia
  • Mycobacterial infections
  • Mycobacterium avium complex (MAC) prophylaxis in HIV patients
  • Pertussis
  • Upper respiratory tract infections in severe beta-lactam allergy

Monitor QTc in patients with increased risk.

Prolongation of QTc interval. Association with increased cardiovascular mortality in observational studies.

  • Other drugs that prolong QTc
  • Increases cyclosporine levels
  • May increase digoxin levels
  • Statins increase risk of rhabdomyolysis

Cost per day based on doses of 250mg PO q24h or 500mg IV q24h.

Antimicrobial class: Macrolide

Pregnancy category: B

Average serum half life: 11-68 hours

Urine penetration: Poor

Lung penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic