Low (20 to 40%)
$$/day (IV)


General Information

Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections especially Enterococcus and Listeria.

Amoxicillin is preferred for PO since ampicillin has boor PO bioavailability.

Allergy and rash as for all beta-lactams.

EBV related rash (not allergy).

Rare: cytopenias, Coombs+.

  • Increased risk of rash with allopurinol
  • Decreased bioavailability of hydroxycholoroquine (separate by 2 hours)
  • Increased risk of seizures with other agents that lower threshold (eg, bupropion, donepezil)

Cost based on dose of 2g IV q4h.

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1-2 hous

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Low (but adequate uptake in inflamed meninges)

Biliary penetration: Therapeutic