General Spectrum of Activity
Fungicidal therapy of yeast or mold infection.
Invasive candidiasis, aspergillosis, cryptococcosis.
Induction therapy for dimorphic fungii (cocci, blasto, histo).
Frequency depends on course, but daily reasonable during initiation.
Same toxicities as conventional Amphotericin B but with less frequency.
Main concern is concomitant nephrotoxins. Use should be minimized during amphotericin therapy.
Antimicrobial class: Antifungal. Polyene. Lipid formulations designed to minimize toxicity.
Pregnancy Category: B (per conventional form)
Average serum half life: 7-10 hours, can be prolonged with very long durations of therapy
Urine penetration: Poor
Lung penetration: Therapeutic
Biliary penetration: Therapeutic