General Spectrum of Activity
Fungicidal therapy of yeast or mold infection.
Induction therapy for dimorphic fungii (cocci, blasto, histo).
Liposomal formulation is preferred for systemic use to minimize toxicity. Conventional formulation is used for any local administrations.
Frequency depends on course, but daily reasonable during initiation.
Infusion related symptoms
Main concern is concomitant nephrotoxins. Use should be minimized during amphotericin therapy.
Antimicrobial class: Antifungal. Polyene
Pregnancy category: B
Average serum half life: 24 hours
Urine penetration: Therapeutic
Lung penetration: Therapeutic
CSF penetration: Suboptimal unless locally administered