Amoxicillin-Clavulanate (Augmentin)

Amoxicillin-Clavulanate (Augmentin)



General Information

Prophylaxis/treatment of bite wounds.

Polymicrobial infections of the respiratory tract or abdomen.

Skin and soft tissue infections.

Covers Gram-negative anaerobes and does not need to be used in combination with metronidazole.

For prolonged therapy, monitor liver enzymes and function.

  • Allergy/rash (immediate or delayed)
  • Note EBV related rash
  • Cytopenias
  • Diarrhea due to clavulanate
  • Hepatotoxicity due to clavulanate - usually mild, liver failure is rare.

Increased risk of rash with allopurinol.

Cost based on 875mg PO BID.

Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

Biliary penetration: Therapeutic