Poor (Less than 20%)

Spectrum of Activity


General Information

Therapy for herpes viral infections (HSV and VZV) including encephalitis.

Prophylaxis of herpes viral infections if recurrent disease or immunocompromised.

For oral treatment indications, consider using valacyclovir instead since increased bioavailability with more convenient dosing.

Follow SCr as appropriate.

Check urine for crystals if AKI suspected.

  • GI upset

  • Phlebitis

  • Increased SCr

  • AKI from crystal nephropathy

Mycophenolate can increase the acyclovir concentration and vice-versa.

May diminish efficacy of zoster or varicella vaccine.

Cost per day based on maximum doses.

Antimicrobial class: Antiviral. Nucleoside analogue.

Pregnancy category: B

Average serum half life: 3 hours

Urine penetration: Therapeutic

CSF penetration: Therapeutic