• Neonates: Vancomycin + Tobramycin
• Infants & children <7 days on ventilator AND no recent antibiotics: Piperacillin-tazobactam + Tobramycin
• Infants & children ≥7 days on ventilator OR recent antibiotics: Piperacillin-tazobactam + Tobramycin ± Vancomycin*

Ampicillin + Tobramycin

• Neonates: Ampicillin + Tobramycin
• >1 month: Ceftriaxone + Vancomycin ± Tobramycin* (*Add Tobramycin for sepsis acquired in the ICU, or for recent post-surgical patients. Consideration should also be made for patients with a tracheostomy or urinary catheter/stent.)

IV: Cloxacillin + Tobramycin

IV: Penicillin + Tobramycin + Cloxacillin

Cloxacillin + Tobramycin

Cloxacillin + Tobramycin

Clindamycin + Tobramycin

Piperacillin + Tobramycin

Ampicillin + Tobramycin + Metronidazole

Ampicillin + Tobramycin + Metronidazole