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Guidelines
Tobramycin - Dosing: Infants & Children

Tobramycin - Dosing: Infants & Children

Dosing Infants & Children

9 mg/kg/dose IV q24h

  • Dose limit: 800 mg/dose prior to TDM
  • Once-daily dosing is the preferred dosing regimen at SickKids

Exclusion Criteria:

  • <5kg
  • Renal failure - acute kidney injury (serum creatinine above 1.5 x baseline or upper limit of age-specific normal range), chronic renal failure, or dialysis
  • Patients for whom other dosing regimens below apply

Females:

  • <7 yrs: 11 mg/kg/dose IV q24h
  • ≥7 yrs: 9 mg/kg/dose IV q24h

Males:

  • <16 yrs: 11 mg/kg/dose IV q24h
  • ≥16 yrs: 9 mg/kg/dose IV q24h

Dose limit: No maximum single dose

2.5 mg/kg/dose IV/IM q8h

  • Dose limit: 120 mg/dose prior to TDM
  • See renal dosing, if renal impairment
  • ≤5 kg:
    • 2.5 mg/kg/dose IV q12h
  • >5 kg:
    • 9 mg/kg/dose IV q24h
    • Dose limit: 800 mg/dose prior to TDM
  • See renal dosing, if renal impairment.

2.5 mg/kg/dose IV q12h for 72 hours

  • Dose limit: 120 mg/dose

2.5 mg/kg/dose IV pre-closure and q12h x 1 dose post-closure

  • Dose limit: 120 mg/dose

5mg/kg PO TID Use IV formulation for PO