Amikacin
Amikacin - Pharmacology

Amikacin - Pharmacology

Pharmacology

Lexicomp (Peds and NeoNatal Lexi Drugs)

Vd: 0.25 L/kg

T1/2: Half-life elimination (renal function and age dependent):

  • Infants: Low birth weight (1 to 3 days): 7 to 9 hours; Full-term >7 days: 4 to 5 hours (Howard 1975)
  • Children: 1.6 to 2.5 hours
  • Adolescents: 1.5 ± 1 hour
  • Adults: Normal renal function: ~2 hours; Anuria/end-stage renal disease: 17 to 150 hours (Aronoff 2007)