Lexicomp (Peds and NeoNatal Lexi Drugs)
Vd: 0.25 L/kg
T1/2: Half-life elimination (renal function and age dependent):
- Infants: Low birth weight (1 to 3 days): 7 to 9 hours; Full-term >7 days: 4 to 5 hours (Howard 1975)
- Children: 1.6 to 2.5 hours
- Adolescents: 1.5 ± 1 hour
- Adults: Normal renal function: ~2 hours; Anuria/end-stage renal disease: 17 to 150 hours (Aronoff 2007)