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Guidelines
Ceftriaxone - Empiric Uses

Ceftriaxone - Empiric Uses

Empiric Uses

  • Brain Abscess: Ceftriaxone + Cloxacillin* + Metronidazole
  • Bacterial Meningitis: Ceftriaxone + Vancomycin
  • VP shunt infection: Vancomycin + Ceftriaxone
  • Severe Respiratory Infections: Ceftriaxone + Vancomycin
  • Ventilator-associated pneumonia: Infants and children, alternative therapy
  • Aspiration Pneumonia: Ceftriaxone ± Clindamycin
  • Sickle Cell Disease: ± Erythromycin (IV) or Clarithromycin (PO)* ± Vancomycin**

  • Septicemia/Bacteremia:

    • Infants >1 month old: Ceftriaxone + Vancomycin ± Tobramycin*

  • Other immunocompromised patients (eg, solid organ transplant, autoimmune disorders): Ceftriaxone + Vancomycin

  • Sickle cell disease with fever: Ceftriaxone ± Vancomycin**

  • Typhoid Fever

  • Orbital Cellulitis: Cloxacillin + Ceftriaxone + Metronidazole

  • Periorbital Cellulitis non traumatic: Moderate-Severe (or if orbital cellulitis not ruled out), IV Ceftriaxone

  • Tick Bites

  • Osteomyelitis (acute): Ceftriaxone + Cloxacillin

  • Sickle Cell Disease: Ceftriaxone + Cloxacillin

  • Conjunctivitis: Older Infants & children