8H dosing or extended intervals for renal impairment (such as Q12H, Q24H etc.)
Trough: 0-30 min before dose. Target: 2.5-10mg/L Peak: 30-60min after end of the infusion. Target: 20-35mg/L
Measure Special Amikacin levels 3 and 6 hours (+/- 30 min) after dose.
Urinalysis, urine output, BUN, serum creatinine, peak and trough serum amikacin concentrations; be alert to ototoxicity
With conventional dosing, typically obtain serum concentration after the third dose; exceptions for earlier monitoring may include neonates or patients with rapidly changing renal function. With extended-interval dosing, usually obtain serum concentration after first, second, or third dose
Not all infants and children who receive aminoglycosides require monitoring of serum aminoglycoside concentrations
Indications for use of aminoglycoside serum concentration monitoring include: