*Uncomplicated: Cultures become negative and fever resolves within 72 hours in a patient without intravascular hardware, no endocarditis, without immunocompromise
Gram negative bacilli: 7-14 days from 1st negative culture, if the catheter is removed
Candida spp: 14 days from 1st negative culture, catheter must be removed
Staph aureus: At least 14 days from 1st negative culture, catheter must be removed