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Guidelines
CLABSI

CLABSI

Routine Precautions

Diagnostic Considerations

Urgent line removal indicated in CVL tunnel infections and uncontrolled sepsis.

Common Pathogens

Coagulase-negative Staphylococci

S. aureus

Gram negative enteric bacilli

Treatment

Vancomycin

+/-

Gram negative coverage

Add gram negative coverage as indicated in immunocompromised patients/hospital-acquired infection

Empiric Sepsis in Patients with CVL

Liver Disease Patients

Severe Beta-Lactam Allergy

Duration of Therapy

Uncomplicated* CONS Infections:

  • 5–7 days if the catheter is removed

  • 10–14 days if the catheter is retained

*Uncomplicated: Cultures become negative and fever resolves within 72 hours in a patient without intravascular hardware, no endocarditis, without immunocompromise

Gram negative bacilli: 7-14 days from 1st negative culture, if the catheter is removed

Candida spp: 14 days from 1st negative culture, catheter must be removed

Staph aureus: At least 14 days from 1st negative culture, catheter must be removed

More Information

Reference

Mermel et al. Clinical Practice Guidelines for the Diagnosis and Management of Intravascular Catheter-Related Infection, 2009 Available Here