Routine Precautions
Urgent line removal indicated in CVL tunnel infections and uncontrolled sepsis.
Vancomycin
+/-
Gram negative coverage
Add gram negative coverage as indicated in immunocompromised patients/hospital-acquired infection
*Uncomplicated: Cultures become negative and fever resolves within 72 hours in a patient without intravascular hardware, no endocarditis, without immunocompromise
Gram negative bacilli: 7-14 days from 1st negative culture, if the catheter is removed
Candida spp: 14 days from 1st negative culture, catheter must be removed
Staph aureus: At least 14 days from 1st negative culture, catheter must be removed
Mermel et al. Clinical Practice Guidelines for the Diagnosis and Management of Intravascular Catheter-Related Infection, 2009 Available Here
Guidelines