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The management of amphotericin B toxicities such as impaired renal function, hypokalemia, and infusion-related reactions are summarized in the algorithms found here.
Hypersensitivity reactions: pruritus, dyspnea, rash, inflammation, urticaria and anaphylaxis may occur.
Ambisome contains hydrogenated soy phosphatidylcholine. Patients who are allergic to soy may experience hypersensitivity reactions to Ambisome.
More frequently diarrhea, nausea and vomiting may occur.
Infrequently chills, fever, rigors, elevated serum creatinine and hypokalemia may occur.
BUN, SCr, liver function tests, serum electrolytes (particularly magnesium and potassium), CBC, vital signs, fluid balance.
Supplied by Pharmacy in syringe or IV bag as a ready-to-administer solution, in a concentration of 0.2 mg/mL to 2 mg/mL in D5W. No further dilution is necessary.
Administer as supplied by Pharmacy. Infuse over 1 to 2 hours.
To minimize nephrotoxicity, sodium loading should be considered in all patients treated with amphotericin B products. The patient must be euvolemic with a normal serum sodium.
Flush lines with Dextrose 5% only prior to and following Ambisome administration. Incompatible with saline solutions and TPN solutions.
Possible Alternative Therapy:
May be dosed on Adjusted Body Weight or Actual Body Weight depending on severity of infection.
Antimicrobials
