Antimicrobials
Remdesivir

Remdesivir

Restricted

N/A
N/A
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Spectrum of Activity

General Information

Inhibits SARS-CoV 2 RNA-dependent RNA polymerase (RdRp).

Remdesivir is an adenosine nucleotide prodrug that is metabolized intracellularly to nucleoside triphosphate metabolite (active). Remdesivir triphosphate acts as an adenosine triphosphate analog and competes for incorporation into RNA chains by the SARS-CoV-2 RdRp which results in delayed chain termination during viral RNA replication. It also inhibits viral RNA synthesis due to incorporation into the viral RNA template.

Avoid use if ALT or AST >5 times the upper limit of normal