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Antimicrobials
Nitrofurantoin

Nitrofurantoin

Low
Excellent
$

General Information

  • Uncomplicated urinary tract infections
  • Nitrofurantoin should not be used to treat UTIs in febrile infants and young children; nitrofurantoin concentrates in the urine and does not reach therapeutic serum and possibly parenchymal concentrations making it ineffective to treat pyelonephritis or urosepsis

ODB Funded (tablet, capsule)

  • Signs of pulmonary reaction
  • Signs of numbness or tingling of the extremities
  • Periodic liver and renal function tests, CBC
  • Urine culture and in vitro susceptibility tests
  • Observe for change in bowel frequency
  • Nitrofurantoin serum concentrations may be increased if taken with food
  • Management: Administer with meals
  • Give with food or milk
  • Do not give to infants <1 month old due to increased risk for hemolytic anemia
  • May discolour urine rust-yellow to brown. Has also been given on an alternate day schedule