Dental Abscess/Facial Swelling of Dental Origin
Amoxicillin and Clavulanate

Amoxicillin and Clavulanate

Medium
Moderate
PO: $

Spectrum of Activity

General Information

Urinary tract infections, complicated community-acquired pneumonia, aspiration pneumonia, skin and soft tissue infections, after initial IV therapy for perforated appendicitis.

ODB funded (tablets, oral liquid)

  • Diarrhea (common)
  • Allergy
  • Non-allergic rash
  • Cytopenias
  • Hepatotoxicity due to clavulanate is usually mild

To reduce gastrointestinal upset:

  • Administer with food
  • Limit clavulanic acid to approximately 10 mg/kg/day if possible in children
  • Use bid dosing schedule (to reduce diarrhea)

Various formulations of suspension exist and are not all equivalent.

Formulary Suspension:

  • Amoxicillin 40 mg/mL and clavulanate 5.7 mg/mL, 7:1 ratio (Clavulin®-200);
  • Amoxicillin 80 mg/mL and clavulanate 11.4 mg/mL, 7:1 ratio (Clavulin®-400)

Formulary Tablets:

  • Amoxicillin 500 mg and clavulanate 125 mg, 4:1 ratio (Clavulin®-500F);
  • Amoxicillin 875 mg and clavulanate 125 mg, 7:1 ratio (Clavulin®-875) $$

Formulary Injection:

  • 1.2 gm: Amoxicillin 1000 mg and clavulanate 200 g, 5:1 ratio $$

Non-Formulary Dosage Forms:

  • Amoxicillin 25 mg/mL and clavulanate 6.25 mg/mL, 4:1 ratio (Clavulin®-125F);
  • Amoxicillin 50 mg/mL and clavulanate 12.5 mg/mL (Clavulin®-250F)

To reduce gastrointestinal upset:

  • Administer with food
  • Limit clavulanic acid to approximately 10 mg/kg/day if possible in children
  • Use bid dosing schedule (to reduce diarrhea)