General Dosing (Based on trimethoprim component)
4-6 mg TMP/kg/dose PO/IV q12h (includes 20-30 mg/kg/dose sulfamethoxazole)
Pneumocystis jiroveci (carinii)
5 mg trimethoprim/kg/dose IV/PO q6h (includes 25 mg/kg/dose sulfamethoxazole)
150mg TMP/m2/day
(5mg/kg/day) PO as a single daily dose or divided BID on 2-3 consecutive days/week
Dose limit: 320 mg TMP/day for 2-3x/weekly regimen
Usual dosing is 75mg/m2 PO q12h every Friday, Saturday, Sunday
5 mg TMP/kg/dose PO once daily (preferred regimen for improved compliance) Dose limit: 160 mg TMP/day
1 single strength (SS) tablet (80mg TMP/400mg SMX) PO once daily (preferred regimen for improved compliance)
≤12 yrs: 2.5 mg TMP/kg/dose PO q12h, 3 times weekly
12 yrs: 1 double strength (DS) tablet (160mg TMP/800mg SMX) PO daily 3 times weekly
2.5-5 mg TMP/kg/day PO as a single daily dose, given 3 times weekly Round to the nearest tablet size Dose limit: 160mg TMP/day
Urinary Tract Infection
4-6 mg TMP/kg/dose PO q12h (includes 20-30 mg/kg/dose SMX)
2-5 mg trimethoprim/kg/dose PO once daily Dose limit: 320mg TMP/day (160mg TMP/dose)
Trimethoprim alone (without SMX) may be preferred as UTI prophylaxis for some patients, i.e. infants <1 month of age, or patients in whom an oral suspension is preferred
