Antimicrobials
Amoxicillin

Amoxicillin

C difficile risk
Low
Oral Bioavailability
Excellent
Cost
PO: $

Dosing

17 mg/kg/dose PO q8h

Preferred regimen Alternative dosing30mg/kg/dose PO q8h

  • Usual adult dose for community-acquired pneumonia: 1g PO q8h Dose limit: 4g/day 45mg/kg/dose PO q12h Dose limit: 4g/day

50mg/kg/dose PO once daily for 10 days Dose limit: 1g/dose

0-5 yrs>5 yrs10 mg/kg/dose PO bid250 mg PO bid

15-24 kg25-34 kg≥35 kg500 mg PO bid750 mg PO bid1000 mg PO bidThe High-Dose regimen is not currently recommended due to lack of proven resistance.

ModerateSevereq12hq24h

General Information

  • Infections caused by S. pneumonia, including pneumonia and AOM

  • Asplenia prophylaxis (alternative to penicillin), alternative to penicillin for Group A streptococcal pharyngitis

ODB funded (capsule, oral liquid)

With prolonged therapy, monitor renal, hepatic, and hematologic function periodically; observe for change in bowel frequency; monitor for signs of anaphylaxis during first dose

May be given with food.