General Dosing
5-7.5 mg/kg/dose PO/IV q6h or 7-10 mg/kg/dose PO/IV q8h Dose limit: 1.8 g/day PO; 2.7 g/day IV
7.5-10 mg/kg/dose IV q6h or 10-13 mg/kg/dose IV q8h Dose limit: 3.6 g/day IV
Use enteral route when possible due to excellent bioavailability, decreased cost, and reduced side effects (e.g. thrombophlebitis)
Chloroquine-resistant falciparum malaria
10mg/kg/dose IV x1, followed by 5 mg/kg/dose IV q8h for 7 days
5 mg/kg/dose PO q6h for 7 days OR 6.7 mg/kg/dose PO q8h for 7 days Dose limit: 2.7 g/day
Use with quinine for chloroquine-resistant malaria only if patient is unable to take doxycycline or tetracycline.
Piperacillin-allergic neutropenic patient with fever
10mg/kg/dose IV q8h Dose limit: 600mg/dose IV
