IV: $$ PO:$$

Spectrum of Activity

General Information

ODB Funded (tablets)


  • Gastrointestinal: Diarrhea (4% to 11%, duration dependent)

1% to 10%:

  • Cardiovascular: Local thrombophlebitis (2%)
  • Dermatologic: Diaper rash (children 3%)
  • Endocrine & metabolic: Increased lactate dehydrogenase (1%)
  • Gastrointestinal: Nausea and vomiting (3% to 7%), unpleasant taste (children 5%)
  • Genitourinary: Vaginitis (≤5%)
  • Hematologic & oncologic: Decreased hematocrit (≤10%), decreased hemoglobin (≤10%), eosinophilia (1% to 7%)
  • Hepatic: Increased serum transaminases (2% to 4%), increased serum alkaline phosphatase (2%)
  • Immunologic: Jarisch-Herxheimer reaction (6%)

With prolonged therapy, monitor renal, hepatic, and hematologic function periodically; number and type of stools/day for diarrhea; and prothrombin time. Observe for signs and symptoms of anaphylaxis during first dose.


  • Give with food
  • Food increases absorption. Suspension may be mixed with a small amount of orange juice, grape juice or chocolate milk immediately prior to administration


  • Give with food, milk or formula. Do not crush tablets – taste is very bitter

Cefuroxime, as sodium:

  • Not to be used for the treatment of meningitis
  • Cefuroxime + Cloxacillin is an inappropriate combination – both are efficacious vs S. aureus

Cefuroxime, as axetil:

  • Dosage for liquid and tablets is not interchangeable