Herpes simplex encephalitis
20 mg/kg/dose IV q8h x 21 days
10mg/kg/dose IV q8h x 21 days
Disseminated HSV infection
10 mg/kg/dose IV q8h
< 12 years: 10mg/kg/dose IV q8h ≥ 12 years: 5-10mg/kg/dose IV q8h
20mg/kg/dose PO q6h Dose limit: 1.6g/day (400mg PO q6h)
Varicella or Zoster Treatment in Immunocompromised hosts
17-20mg/kg/dose IV q8h
500 mg/m2/dose IV q8h
20mg/kg/dose PO q6h x 5 days
Mild-Moderate mucocutaneous HSV infections
10-20mg/kg/dose PO q6h Dose limit: 800 mg/day PO (200 mg PO q6h)
HSV prophylaxis in Immunocompromised hosts
13 mg/kg/dose PO q8h or 20 mg/kg/dose PO q12h
HSV prophylaxis in HSCT recipients
250 mg/m2/dose IV q8h
250 mg/m2/dose IV q12h
Lung Transplant Prophylaxis
≤12 years: 250 mg/m2 PO q8h x 3 months Dose limit: 600mg/day (200mg/dose)
Varicella in an immunocompetent host
Dose Limit: 3.2 g/day PO (800 mg PO q6h)
Intestinal Transplant Patients
250 mg/m2 PO q8h x 12 weeks Dose Limit: 600 mg/day (200 mg/dose)
