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Acyclovir
Renal

Renal

Moderate (GFR 25-50 mL/min)

q12h

Severe (GFR 10-25 mL/min)

q24h

Failure (GFR < 10 mL/min)

50% of dose q24-48h. Start with q24h and adjust to q48h as needed, in consultation with pharmacy

Hemodialysis/Peritoneal dialysis

50% of dose q24h; Give after hemodialysis