Firstline - Clinical Decisions

Antimicrobials

Ampicillin

C difficile risk Low

Oral Bioavailability N/A

Cost IV: $$

Spectrum of Activity

Antibiogram Data

Dosing

Neonatal

Infants & Children

Renal

General Information

Empiric Uses

Funding

ODB funded

Adverse Effects

Allergy, rash
Non-allergic rash occurs in 5% to 10% of children and is a generalized dull red, maculopapular rash, generally appearing 3 to 14 days after the start of therapy
Rare: cytopenias, positive Coombs

Drug Monitoring

With prolonged therapy, monitor renal, hepatic, and hematologic function periodically
Observe for change in bowel frequency
Observe for signs of anaphylaxis with first dose

Dietary Concerns

Food decreases ampicillin absorption rate; may decrease ampicillin serum concentration.
Management: Take at equal intervals around-the-clock, preferably on an empty stomach (30 minutes before or 2 hours after meals). Maintain adequate hydration, unless instructed to restrict fluid intake.