Restricted Indications
Infants less than 1 month corrected age (ceftriaxone may cause bilirubin encephalopathy)
Patients with liver/gallbladder/biliary disease, including perioperative prophylaxis in liver transplantation (ceftriaxone may cause biliary sludging)
Restricted Prophylaxis Indications
Peri-operatively in liver transplantation
Prophylaxis against Neisseria meningitidis where rifampin and ceftriaxone are contraindicated
Other Indications
Infectious Diseases approval required
Ceftriaxone is the preferred 3rd generation cephalosporin due to ease of administration, cost
