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Antimicrobials
Ceftazidime

Ceftazidime

Restricted

High
N/A
IV: $$$

Spectrum of Activity

Antibiogram Data
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General Information

  • Brain Abscess (excluding neonates and patients with CSF shunts): Chronic otitis externa - Ceftazidime + Cloxacillin + Metronidazole
  • VP shunt infection:
    • If concerned about Pseudomonas aeruginosa: Vancomycin + Ceftazidime

EAP (Injection)

1% to 10%:

  • Dermatologic: Pruritus (<2%), skin rash (<2%)
  • Endocrine & metabolic: Increased lactate dehydrogenase (6%), increased gamma-glutamyl transferase (5%)
  • Gastrointestinal: Diarrhea (1%)
  • Hematologic & oncologic: Eosinophilia (8%), positive direct Coombs test (4%; without hemolysis), thrombocythemia (2%)
  • Hepatic: Increased serum ALT (7%), increased serum AST (6%), increased serum alkaline phosphatase (4%)
  • Hypersensitivity: Hypersensitivity reactions (2%)
  • Local: Inflammation at injection site (1%), injection site phlebitis (1%)
  • Miscellaneous: Fever (<2%)
  • Renal function periodically when used in combination with aminoglycosides; with prolonged therapy also monitor hepatic and hematologic function periodically; number and type of stools/day for diarrhea
  • Observe for signs and symptoms of anaphylaxis during first dose
  • Monitor prothrombin time in patients at risk for increased INR (nutritionally deficient patients, prolonged treatment, hepatic or renal disease)